David, that's an interesting experience. An inch of shift is an awful lot...I don't know how far you were shooting but that's a lot even if it was a fairly long distance like 75 yards. I have on occasion seen a substantial change in POI as a squeaky clean barrel gets leaded in, but nothing that significant when simply moving between different kinds of ammo. I do the same as you...once I find the best grouping pellet for a particular rifle, I zero with it and mostly shoot that particular one. But any time I get some new pellets to try, I test them without cleaning either before or after. Then when I'm done, I make a habit of rechecking the zero with the original pellet just to be sure and it's rare that I can discern a shift. Those few times I could see a difference, it either went back on its own after a pellet or two or was so subtle that I couldn't separate it from the myriad of other variables like the wind, my hold, or the like. Having said that, it occurs to me that since you have been testing slugs, there was an opportunity for highly accelerated leading due to the increased contact area. Maybe that's the difference.As to the question of cleaning in between when evaluating different pellets, I used to think it matters based on the wisdom of the interwebs but don't any more after doing my own testing. To be clear, I am not asserting that seasoning a barrel is bunk. A thoroughly clean barrel and a lightly leaded barrel barrel will usually group differently enough to notice, and there may indeed be some improvement in some cases after you've put 10, 20 or 30 of a particular pellet down the barrel. I'm just saying that the process of weeding out "bad" pellets from the good pellets (those favored by your gun) is coarse enough that I think fretting over cleaning and reseasoning is a waste of time.To give an example, here is a sheet of 16 groups (16 different pellets) shot back-to-back at 25 yards.Notice there are a few sub-MoA groups (green) despite no cleaning in between and that's plenty discriminating enough to recognize which ones are worthy of further testing and which ones can be returned to the shelf.