I think it will seal just fine.... my suggestion was to make it removable.... Use JB Weld and you'll break the screw off before it will ever come out....Bob
IMO, an 8-32 grub screw of 1/4" length would suffice...would seal it with blue loctite. I use blue loctite on all my fill fittings...leave it overnight. Easy to dis assemble if needed, and blue loctite is available darn near anywhere.Al
small 1/8" x 1/2" set screw, etc. with locktite = no problem, however if it were say 1" or larger, then you could have a problem.