No...keep all the air in the tank that you can...otherwise the pump will need to replace it! Don't waste tank pressure for no reason. Hook the tank up to the pump but keep the tanks valve closed. With the bleeder screws on the pump OPEN, turn on the pump...then close the screws once it is running.... you will see the pressure on the tank and pump gauges start to rise. Then you can slowly open the tank valve to let pressure begin entering the tank. Before starting, I like to take note of the tank pressure... then when the pump gets running, open the valve once the pump pressure gets to about that point. Once up to pressure...I quickly close the tank valve and open the pump bleeder screws. Then turn off pump with the screws open.